Multifunctional Black Bioactive Ceramic Materials Developed Recently


Posted on: 27 December 2020 by chen shanshan

Multifunctional Black Bioactive Ceramic Materials Developed Recently

Bioceramic materials have a long history of being used for repairing human hard tissues. From bioinert materials (such as alumina and zirconia, etc.) to bioceramics (such as phosphate and silicate bioceramics, silicon-based bioglass, etc.) with both biological activity and degradability, their physiological function requirements are no longer simple tissue filling substitutes, but tissue engineering materials that can induce tissue regeneration, regulate cell growth and functional differentiation. There is increasing evidence that specific bioactive ceramic materials have the effect of promoting the revitality of soft/hard tissue-specific cells and are widely used in tissue defect repair of bones, teeth, and skin. However, there are many special tissue injuries in clinical practice, such as tissue defects after surgical resection of bone tumors or skin cancer tissues, which require the removal of residual tumor cells before repairing the tissue defects to avoid tumor recurrence. In order to realize the dual functions of cancer therapy and tissue regeneration, previous studies have prepared photothermally functionalized bioactive ceramic materials by compounding bioactive ceramics with photothermal reagents with cancer therapy functions. Despite an effective strategy, the long-term safety of photothermal nanoreagents in vivo has yet to be investigated. Therefore, how to realize the integration of tissue regeneration of bioactive ceramic materials themselves and the therapeutic function of diseases such as tumors without introducing foreign additives is particularly important.Recently, the research team led by Wu Chengtie and Changjiang, researchers at the Shanghai Institute of Silicate, Chinese Academy of Sciences, has made progress in the study of multifunctional black bioactive ceramic materials. The research team developed a new generation of "black bioactive ceramics" by thermally reducing traditional white bioactive ceramic materials (silicates and phosphates, etc.), expanding the application field of traditional bioactive ceramic materials from tissue regeneration to the treatment of diseases such as tumors. The relevant research results were published in Advanced Materials under the title Black Bioceramics: Combining Regeneration with Therapy and applied for a patent.

The team used magnesium thermal reduction to thermally reduce traditional white bioactive ceramic powders to prepare a series of black bioactive ceramic materials, including bioactive ceramics with two systems: silicate (i.e., CaSiO3, MgSiO3) and phosphate (i.e., Ca3 (PO4) 2, Ca5 (PO4) 3 (OH)). Compared with traditional white bioceramics, black bioceramics have a large number of oxygen vacancies and structural defects in the crystal interior, and their degradation properties are significantly improved, which has a better promoting effect on cell biological activities such as adhesion, spreading, proliferation, migration and differentiation of osteoblasts and skin cells.

In animal experiments of chronic skin trauma and massive bone defect repair, black bioceramics are significantly superior to white ceramics for skin and bone tissue repair, showing a significant promotion of soft/hard tissue multifunctional revitality. In addition, under low-power near-infrared light irradiation, black bioactive ceramic materials show significant photothermal heating effect, which can lead to tumor cell death around the materials, successfully inhibit the growth of skin cancer and bone tumors in vivo experiments, and have excellent photothermal anti-tumor effect. In summary, black bioactive ceramic materials have multifunctional characteristics such as promoting the revitalization of a variety of tissues and cancer treatment, and this study expands the application range of bioactive ceramics from tissue regeneration to cancer treatment, strongly promoting the subject development and clinical application of bioceramics.

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Aiden Cartwright posted 29 December 2020

Amazed to read about the invention if. This multifunctional material. Hope that this would work amazingly to facilitate the best in life. Otherwise, you can get careers booster reviews to make your work better than others. The fruitful results generate from this blog are best. So never forget to read this and visit this wonderful blog.

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