Biocompatible Glue That Can Seal Injured Tissues and Stop Bleeding Found

Rectangle_large

Posted on: 08 October 2021 by chen shanshan

Biocompatible Glue That Can Seal Injured Tissues and Stop Bleeding Found

Engineers at MIT were inspired by the sticky substance attached to the rock by barnacles and designed a powerful biocompatible glue that can seal injured tissue and stop bleeding.

 

This new paste can adhere to the surface even if it is covered by blood stains, and can form a tight seal in about 15 seconds. Researchers say this glue can provide a more effective way to treat trauma and help control bleeding during surgery.

 

"We are solving the problem of adhesion in a challenging environment, that is, a humid, dynamic environment of human tissues. At the same time, we are trying to transform this basic knowledge into actual products that can save lives," Xuane Zhao, a professor of mechanical engineering, civil and environmental engineering at the Massachusetts Institute of Technology (MIT) and one of the senior authors of the study, said.

 

Christoph Nabzdyk is a cardiac anesthesiologist and critical care physician at the Mayo Clinic in Rochester, Minnesota, and the senior author of this paper published in the journal Nature Biomedical Engineering. YukHyunwoo, a research scientist at MIT, and JingjingWu, a postdoctoral fellow, are the main authors of this study.

 

Zhao said that finding a way to stop bleeding is a long-standing problem, but it has not yet been fully resolved. Sutures are usually used to close wounds, but stitching in place is a time-consuming process, which is usually impossible for emergency personnel in emergency situations. Among military personnel, blood loss is the leading cause of death after traumatic injuries, and among ordinary people, blood loss is the second leading cause of death after traumatic injuries.

 

In recent years, some materials that can stop bleeding, also known as hemostatic agents, have been sold on the market. Many of these are made up of patches containing clotting factors, which help the blood to clot on its own. However, it takes a few minutes to form a seal and does not always work on heavily bleeding wounds.

 

Zhao's laboratory has been working on solving this problem for many years. In 2019, his team developed a double-sided tissue tape and demonstrated that it can be used to close surgical incisions. This tape is inspired by the sticky material used by spiders to catch prey in humid conditions. It contains charged polysaccharides that can absorb water from the surface almost instantaneously, removing small dry areas where glue can attach.

 

For the new tissue glue, the researchers once again drew inspiration from nature. This time, they focused on the barnacle. Barnacles are small crustaceans that can attach to rocks, ship hulls, and even other animals such as whales. These surfaces are wet and often dirty, which make adhesion difficult.

 

"This has attracted our attention," Yuk said. "This is very interesting because to seal the bleeding tissue, you have to fight not only with dampness, but also with the contamination of the outflow blood. We found that this creature living in the marine environment is doing exactly the same thing we do when we deal with complex bleeding problems."

 

Researchers' analysis of barnacle gum shows that it has a unique composition. The sticky protein molecules that help the barnacle attach to the surface are suspended in an oil that repels water and any contaminants on the surface, so that the sticky protein is firmly attached to the surface.

 

The MIT research team decided to simulate this glue by modifying an adhesive they had previously developed. This viscous material consists of a polymer called polyacrylic acid and an organic compound called NHS ester. NHS ester provides viscosity, while chitosan is a sugar that can enhance the strength of the material. Researchers freeze thin flakes of this material, grind them into particles, and then suspend these particles in medical silicone oil.

 

When the resulting paste is applied to a wet surface (e.g., tissue covered with blood), the oil repels possible blood and other substances, cross-links the adhered particles, and forms a tight seal on the wound. The researchers' experiments in mice showed that within 15 to 30 seconds after applying the glue, the glue would solidify and bleeding would stop by gentle pressure.

 

The researchers said that compared with the double-sided tape designed by the researchers in 2019, one advantage of this new material is that the paste-like material can be molded into a shape suitable for irregular wounds, and the tape may be more suitable for sealing surgical incisions. Or connect medical equipment to the organization. "The moldable paste can flow in, fit any irregular shape and seal it," Wu said. "This allows users to freely adjust it to fit various irregularly shaped bleeding wounds."

 

In a trial in pigs, Nabzdyk and colleagues at the Mayo Clinic found that the glue quickly stopped liver bleeding and was faster and more effective than the hemostatic agents on the market they compared. It works even when pigs are injected with a strong blood thinner (heparin) so that blood does not spontaneously form clots.

 

Their research has shown that this seal can remain intact for several weeks, giving the underlying tissues enough time to heal itself, and that the inflammation caused by this glue is very small, similar to the inflammation caused by currently used hemostatic agents. After a few months, this glue will be slowly absorbed in the body. If the surgeon needs to enter the wound for repair after the initial application, it can also be removed in advance by applying a solution that dissolves it.

 

The researchers now plan to test the glue on larger wounds, and they hope to prove that the glue is useful for treating traumatic injuries. They also envisioned that this technique might be useful during surgical procedures, because surgeons usually spend a lot of time controlling bleeding.

 

Nabzdyk said: "We are technically capable of performing many complex operations, but we have not really progressed so fast in terms of the ability to quickly control particularly severe bleeding."

 

Another possible application is to help patients who have plastic tubes inserted into blood vessels to stop bleeding, such as those used for arterial or central venous catheters or extracorporeal membrane oxygenation (ECMO). During ECMO, a machine is used to pump the patient's blood out of the body for oxygen. It is used to treat patients with severe heart and lung failure. The catheter is usually inserted for several weeks or months, and bleeding at the insertion site may cause infection.

Share with friends



Do you agree with this Blog? Agree 0% Disagree 0%
You need to be signed in to rate.
Profile_user

aliana ales posted 04 November 2021

some great concepts are explained in this given link. I reached this info by searching what are the benefits about cardiologist. I am glad that I found this link as it was a great help.

Profile_user

soveda4966 soveda4966 posted 02 December 2021

Hello just wanted to give you a quick heads up. The text in your article seem to be running off the screen in Internet explorer. I’m not sure if this is a format issue or something to do with browser compatibility but I figured I’d post to let you know. The design and style look great though! Hope you get the issue fixed soon. Kudos Онлайн-виза в Индию

Profile_user

soveda4966 soveda4966 posted 06 December 2021

Hi I wish to to talk about the remark here concerning you to definitely have the ability to inform you simply how much i personally Liked this study. I must run off to aTurkey Day time Supper however wanted to leave ya a simple comment. We preserved you So will end up being returning following function to see more of yer high quality articles. Continue the quality function. Ινδία eVisa

Profile_user

aliana ales posted 07 December 2021

Wipe it with wet cloth, but don't rinse it with running water. Panana Furniture Online UK 384208979 Based on the above, I believe everyone will know why furniture doesn't need mortise and tenon structure now.

Profile_user

aliana ales posted 08 December 2021

My husband and i were quite satisfied Raymond could deal with his web research through your precious recommendations he received while using the web site. It’s not at all simplistic to just happen to be giving out secrets and techniques that many other folks may have been selling. So we figure out we need the writer to thank for that. Those explanations you have made, the easy web site navigation, the relationships you will make it possible to instill – it is all terrific, and it’s aiding our son in addition to us believe that that subject matter is brilliant, and that’s pretty mandatory. Thanks for everything! togel hari ini

Profile_user

killer smile posted 09 December 2021

Great site keep posting more! boston bookkeeper

Profile_user

looney looneyhans posted 09 December 2021

Awesome! Learned alot thanks so much keep posting more.   https://fencingstlouis.com

Profile_user

ida sanka posted 10 December 2021

thanks for sharing this with us! love it! <3 auto wrap near me

Profile_user

woham woher posted 12 December 2021

I was suggested this blog by my cousin. I’m not sure whether this post is written by him as nobody else know such detailed about my difficulty. You are incredible! Thanks!

Profile_user

woham woher posted 14 December 2021

June Havens (Cameron Diaz) and Roy Miller (Tom Cruise) collide with each other at an airport. Manchester Digital Angency

Profile_user

looney looneyhans posted 15 December 2021

Great site thanks admin. More power.   https://paintersidahofalls.com

Profile_user

killer smile posted 16 December 2021

interesting post keep posting more!  bathroomremodelelpaso.com

Profile_user

lemeyiy711 lemeyiy711 posted 20 December 2021

digitalesque Grow Your Business Our approach is to provide you with an all-in-one package that gives you simple access to a team of experienced professionals.Web Development, Content Creation, Search Engine Optimization, Ad Management, Social Media Management, etc…You can focus on making your business the best it can be, we will bring the people to you. https://www.digitalesque.com

Profile_user

lemeyiy711 lemeyiy711 posted 20 December 2021

trtrecovery Our residential treatment programs are designed to help patients identify and work on physical and psychological problems that resulted from their drug and/or alcohol addition, while in a safe and supportive living environment. Therapies include Cognitive Behavioral Therapy, Individual & Group Therapy, Family Therapy, and more. http://trtrecovery.com

Profile_user

aliana ales posted 21 December 2021

Find best birthday surprise delivery singapore ​​& Crate your own surprise gift box through the bundles we have available and let us handle your surprise birthday gift delivery. Celebrate their special day with a bright surprise

Profile_user

soveda4966 soveda4966 posted 22 December 2021

Discover physical therapy Richardson ​if you are looking for physical therapy services in Richardson? OneRehab multispecialty clinic is the best. We design physical therapy exercises to help you recover from various physical injuries and medical procedures. Additionally, we offer practical information to educate you about your condition. The info ensures you go safely through physical and occupational therapy exercises

Profile_user

woham woher posted 22 December 2021

Find best Dusar Duschkabinen ​Dusar shower stalls in Germany. Save 30% when buying directly from the manufacturer, In our exclusive online shop you will find our range of bath tub attachments , barrier-free walk in showers and many other solutions for your dream bathroom. If you are unsure which shower solution is the right one for your bathroom, let us advise you free of charge in advance, visit our website to contact us.

Profile_user

soveda4966 soveda4966 posted 22 December 2021

sàn gỗ ngoài trời tên tiếng anh là wood plastic composite flooring có cấu tạo từ bột gỗ và bột nhựa cùng các chất phụ gia khác qua quá trình đùn ép, lên khuôn tạo thành các thanh sàn. Khi thi công lắp đặt cùng hệ xương gỗ hoặc xương sắt sẽ tạo thành sàn gỗ.

Profile_user

soveda4966 soveda4966 posted 22 December 2021

Inbound takeaway courier promotion|Various special party set menus for free choice. Hong Kong people’s first choice for gourmet food at the meeting 到會 ​catering service company|Kama Delivery Catering, Visit this website & get Multi-person attendance package, Optional lunch box for one person, Free shipping and free exchange and return polices as well as Free snacks at FPs Checkout. Don't miss this chance.

Profile_user

aliana ales posted 23 December 2021

Almost every new building, private or business, now contains infrastructure for such a system and not just… Its advantages and beyond being a basic tool for managing wired or wireless communication in many offices and factories, if you add a few accessories, each intercom system אינטרקום לבניין ​becomes a major part of any security system, from very simple to Very complex. Communication and security, it turns out, are products that the general public finds very useful, positive and sometimes really necessary

Profile_user

woham woher posted 23 December 2021

Aw, this was an exceptionally good post. In thought I would like to put in writing like that additionally – taking time and actual effort to produce a very good article… but exactly what do I say… I procrastinate alot and also no indicates find a way to go done. VISTO DE TURISTA PARA AMÉRICA

Profile_user

aliana ales posted 23 December 2021

Cartoon Art is a new photo cartoonizer software released by PrimaCartoonizer.com. how to convert photo into cartoon ​with unique style than Prima Cartoonizer, it includes a new colored cartoon effects.

Profile_user

soveda4966 soveda4966 posted 23 December 2021

Shop affordable moissanite engagement rings ​for women, Allegra N Co offering Premium collection of Cheap Moissanite Rings Including Rose Gold, Oval Moissanite Engagement Rings, Vintage Moissanite Engagement Rings Emerald Cut Moissanite Engagement Rings Free Delivery Across US.

Profile_user

soveda4966 soveda4966 posted 23 December 2021

Shop affordable moissanite engagement rings ​for women, Allegra N Co offering Premium collection of Cheap Moissanite Rings Including Rose Gold, Oval Moissanite Engagement Rings, Vintage Moissanite Engagement Rings Emerald Cut Moissanite Engagement Rings Free Delivery Across US.

Profile_user

aliana ales posted 23 December 2021

Export Gmail™ emails and labels to PDF with one click , Save emails or labels to PDF directly from Gmail™. This extension lets you easily save Gmail™ emails as a PDF document. Our service works in just 1 click, and you're done! Save email messages as a file

Profile_user

aliana ales posted 23 December 2021

Java burn ingredients according to john barban javaburn ingredients are green tea extract green tea has long been known to have beneficial effects on the body due to the polyphenols and caffeine content it can help you lose weight it also has a very potent antioxidant that protects your body from weight gain javaburn

Profile_user

aliana ales posted 23 December 2021

Explore synogut supplement review, Synogut is a supplement clinically proven to help the digestive system better assimilate nutrients from food, combat stomach discomfort, and ease abdominal. If you suffer from indigestion, digestive pains, or a chronic stomach ache, the solution could be as simple as taking a supplement.

Profile_user

aliana ales posted 23 December 2021

Explore circadiyin reviews ​- Does it Really Works or Scam for Weight Loss ? circadiyin reviews , Another way to help keep off weight and keep your weight down is to take a supplement such as CircadiYin The reason we say another way is because it won't... Explore it by clicking anchor text.

Profile_user

aliana ales posted 24 December 2021

Discover birds for sale near me ​Your one stop parrots for sale site for the most adorable parrots you can find. We have a wide collection of these charming birds; we have several species of parrots that are on sale. Such parrots are budgies, cockatiels, african grey, rosie bourke, macaw etc.

Profile_user

aliana ales posted 24 December 2021

Discover best budget running shoes. Athleticgen is about fitness through running and exercises . Learn the best running shoes, exercise equipment, running gear and running guides by clicking here, Thank You.



Do NOT follow this link or you will be banned!