An Overview of the Global Bispecific Antibody Therapeutics Market

Rectangle_large

Posted on: 15 October 2021 by chen shanshan

An Overview of the Global Bispecific Antibody Therapeutics Market

Antibodies, a major component of adaptive immunity, play a critical role in protective and pathogenic immune responses. In recent years, a wide range of antibodies is discovered as candidates of cancer therapeutic agents, including the reconstructive molecules, bispecific antibodies (BsAbs).

 

About Bispecific Antibody

 

Bispecific antibodies, as its name indicates, consists of two antigen-binding sites, which can simultaneously bind two separate and unique antigens (or different epitopes of the same antigen). This structure is typically designed to bind to two targets, one on a cancer cell and one on an immune cell, activating or redirecting immune effector cells with the goal of getting the immune cell to kill the cancer cell by antibody-dependent cell-mediated cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), complement-dependent cytotoxicity (CDC) and other cytotoxic mechanisms.

 

Unique biological and pharmacological properties, as well as availability in different formats, broaden bispecific antibody applications and make it a novel and promising antibody therapeutic agent in the field of genetic disorders, hematological malignancies, autoimmune disorders, inflammatory disorders, eye disorders, skin disorders, etc.

 

Existing Market of Bispecific Antibodies Therapeutics

 

Inspired by the approval of two bispecific antibodies, namely Blincyto® (2014) and Hemlibra® (2017) for therapeutic use, a number of bispecific antibody companies and technology providers have devoted themselves to advancing the development of pipeline drug candidates. As a consequence, near 50 new formats of BsAbs are produced in recent years relying on advanced antibody engineering techniques. For instance, bispecific fusion protein, a major format of bispecific antibodies, could be generated by linking other proteins to the antibody or antibody fragments to add more functionality or specificity.

 

Clinical trials based on bispecific antibodies also contribute to the increasing popularity and therapeutic potentials. It's reported that an increase from 51 in 2014 to over 300 in 2019 was observed in the cumulative number of bispecific antibodies related studies, and over 300 bispecific drug candidates are currently in clinical or preclinical stages.

 

Challenges

 

However, building a safe and effective bispecific antibody candidate is more than challenging. The reconstructed antibody therapeutics are anticipated to activate immune cells while too many immune cells could cause cytokine release syndrome or other side effects. Specific challenges of developing bispecific antibody therapeutics could arise at various stages. But the main restraint in the development of bispecific antibodies falls on manufacturing problems, such as low expression yields, product instability, and immunogenicity. As a result, technologies that meet the growing development demand for new bispecific antibody therapeutics with better predictive screening capabilities and higher throughputs are required.

 

To specifically evaluate the structure, function, and quality of the bispecific antibody products in the early process, researchers have to utilize sophisticated and time-consuming analytical techniques, such as enzyme-linked immunosorbent assay (ELISA) and liquid chromatography–mass spectrometry. However, the highly competitive and economically driven bispecific antibody therapeutic market emphasizes a challenge in balancing speedy delivery without compromising quality.

 

Moreover, the stricter selection criteria for bsAbs than those for monospecific antibodies bring more challenges in screening and antibody characterization to identify cell lines with the highest quality and productivity. The next-generation platform for bispecific antibody sequencing like database-assisted shotgun sequencing (DASS) technology could be helpful for the sequencing of unknown BsAb antibodies, especially if there is no record of amino acid sequences of a specific antibody in the database.

 

The outlook of Bispecific Antibody Therapeutics Market

 

Reports from several market research companies have concluded that the healthcare landscape all over the world is more inclined towards using antibodies for the treatment of cancer, in which the global bispecific antibody market has surged in the past few years because its feature of targeting two different epitopes simultaneously has increased the overall therapeutic success rate.

 

Encouraged by factors like increasing prevalence of cancer cases, increased failure rate of other cancer therapies, and rising geriatric population, the bispecific antibody therapeutic market, not only opportunities in cancer treatment, is pegged to value $12 billion by 2026.

 

BsAbs is emerging as the next novel wave of biologics!

Share with friends



Do you agree with this Blog? Agree 0% Disagree 0%
You need to be signed in to rate.
Profile_user

jenny john posted 21 October 2021

A great content material as well as great layout. Your website deserves all of the positive feedback it’s been getting. I will be back soon for further quality contents.   cyber threats

Profile_user

Gabriella gabriella123 posted 03 November 2021

The quality and quantity of work produced in here is absolute informative. Thanks for sharing. My site::. 메이저사설토토

Profile_user

aliana ales posted 04 November 2021

Gambling website 789bet or 789betting is the best online gambling website and legal online casino service, providing online gambling services, online football betting, online slots, online lottery, online baccarat, online games, full range, full range, high return, link system to get wealth. ninja168

Profile_user

telobi3311 telobi3311 posted 07 November 2021

The content is utmost interesting! I have completely enjoyed reading your points and have come to the conclusion that you are right about many of them. You are great, and your efforts are outstanding! 토토

Profile_user

telobi3311 telobi3311 posted 09 November 2021

Premium eyelid anti aging device that helps treat sagging eyelid skin. EvenSkyn:registered: is a manufacturer of premium , Laser Hair Removal, Anti Aging, andhelping men and women have smooth, hair free skin, Please click to visit our website for more information, Thank You. skin care device

Profile_user

telobi3311 telobi3311 posted 10 November 2021

Countquick Accounting Services provides support to fix Banking error code 101. We help clients when they are unable to get bank feeds in Qb. We also provide support when user don't know How to resolve error code -6190, -816 in qb desktop ​. Best Quickbooks support |18004769446

Profile_user

aliana ales posted 11 November 2021

Explore Dormi Dream headphones are the most comfortable sleep sleep headphones headband. Secured in a soft headband, they are comfortable even for side-sleepers. Shorter charging time, a thinner headband are the most comfortable headphones to sleep in Shop now! & and get 10% OFF your order! sleep headphones headband

Profile_user

telobi3311 telobi3311 posted 13 November 2021

Betflix adalah salah satu situs yang sudah menjadi partner resmi dari provider - provider kelas dunia yang berkualitas seperti Pragmatic Play, SpadeGaming, PlayTech, JokerGaming, Pretty Gaming, Asia Gaming, SBOBET dan masih banyak lagi pilihan yang tersedia yang bisa membuat anda tidak akan bosan.

Profile_user

aliana ales posted 13 November 2021

Permit Studio is a full-service permit expediting and permit management company in Chicago. We are offering the 36 different Permit expediting chicago permit services ​in Chicago.We can help you with an array of permit expediting and permit management tasks in Chicago. Adding us to your team will save you time and keep you from making some costly mistakes

Profile_user

aliana ales posted 13 November 2021

As the pneumonia epidemic continues, more and more people will have to order to eat, but many people are relatively new to ordering takeaways, and most people think that traditional takeaways are the first for many people to eat. Visit this website & get 外賣服務 (Takeaway Services),The service that will be used is actually a lot of small gatherings , mini parties as small as two or three people will be called. Free shipping and free exchange and return polices as well as Free snacks at FPs Checkout. Don't miss this chance. Attendance Discount|Latest Books Promotion|Kama Delivery Catering. 外賣服務

Profile_user

aliana ales posted 15 November 2021

Click here ​to check the list of best Telescope price online complete buyers guide which helps you to choose best one and these are available at low Price.You will also get info like, Features of Telescope, Types of Telescopes, Buyers guide for Telescope and more.

Profile_user

aliana ales posted 15 November 2021

If you are looking for a wig that gives you a hair solution with freedom to style and colour your wig whenever you want to, a human hair wig is your best option. Shop online with us and choose from the best human hair wigs Canada.

Profile_user

aliana ales posted 15 November 2021

The #1 OKR Software ​For Driving Growth, Project Task and Milestone Management, Business Accounting - Invoicing and Expense Management and Objective Key Results Management. Skhokho is a one-stop software for business managers to run their operation easily and effectively. It provides the most comprehensive set of tools to manage every aspect of business management from Human Resource management(HRM), Customer Relationship Management (CRM).

Profile_user

aliana ales posted 17 November 2021

Find best Duschen mit KLick und Fest Profiel in Germany. Save 30% when buying directly from the manufacturer, In our exclusive online shop you will find our range of bath tub attachments , barrier-free walk in showers and many other solutions for your dream bathroom. If you are unsure which shower solution is the right one for your bathroom, let us advise you free of charge in advance: 02639 962799-0. Duschen mit KLick und Fest Profil

Profile_user

aliana ales posted 17 November 2021

Kerala Board SSLC Model Question Paper 2022 Download Subject Wise for Malayalam & English Medium Students Along with Kerala SSLC Important Questions Subject Wise Kerala SSLC Question Paper

Profile_user

telobi3311 telobi3311 posted 18 November 2021

We exist to provide you the highest quality engagement and Affordable Engagement Rings ​​prices. Our rings are handcrafted from start to finish, without breaking the bank. Because we believe that a wedding does not have to cost you a fortune.

Profile_user

telobi3311 telobi3311 posted 18 November 2021

Explore health care products reviews , Our reviews are not just written without checking their details. We use verified sources and references for that. This’s because we are required to deliver honest transparent reviews.You can always check all the verified references and sources used in this review at the bottom of this page.

Profile_user

telobi3311 telobi3311 posted 18 November 2021

Explore health care products reviews , Our reviews are not just written without checking their details. We use verified sources and references for that. This’s because we are required to deliver honest transparent reviews.You can always check all the verified references and sources used in this review at the bottom of this page.

Profile_user

aliana ales posted 18 November 2021

Explore Need Health - The Best Place To Aquire The Needed Health, Visit our website to get info about the best brain health supplement, As We are constantly learning about how amazing the human brain is. It’s many more powerful than even the latest, most advanced technology. While you can’t live in fear of injury, you can stay on top of your health to minimize the odds of developing an issue, and to know what actions to take if something goes wrong.

Profile_user

aliana ales posted 18 November 2021

If You are looking to buy supplements for your health care, Clinic Review is a website Offers Reviews Of Supplements ​like: CircadiYin Weight Loss supplement Reviews – Scam Weight Loss or Effective, SynoGut Reviews – SynoGut For Healthy Digestion, Harmonium Sleep Support Review – Safe Sleep Fixing Formula? & more, Please visit this site for getting valuable information, Thank Yo

Profile_user

Brown Brown posted 23 November 2021

Nice post. I was checking constantly this blog and I am impressed! Extremely helpful information specially the last part I care for such info a lot. I was seeking this particular information for a very long time. Thank you and good luck. shipping containers gold coast

Profile_user

telobi3311 telobi3311 posted 24 November 2021

Hey, Find a personal trainer near you with UKFitness Pro, the nation’s largest database of personal trainers! personal trainer finder ​in UK by just visiting this website Just enter your location into the search box above, hit search, then message one of the qualified personal trainers near you.

Profile_user

aliana ales posted 26 November 2021

Life is stressful and tiring. You accumulate all kinds of tension and bad habits that make your lumbar and cervical vertebrae ache. Your eyes, riveted on screens all day long, push you to take bad postures, which does not leave you unscathed. Acupressure mat

Profile_user

aliana alis posted 26 November 2021

Explore The Exclusity, It's NOT About Scrolling - It's About Connecting - Know The Difference. Click here ​and search for anything. We Empower Consumers & Entrepreneurs in 3 Core Ways. Search Popular Categories.

Profile_user

telobi3311 telobi3311 posted 28 November 2021

Incoming takeaway service 外賣推介 Recommendation & Promotion|Exclusive free shipping offer|Get Your food at meeting 到會美食 or 2-100 people set meal|Pre-ordered party food delivered on the same day|Kamadelivery.com, They also accept large-scale catering services for large and small birthday parties, banquets, company events, friend gatherings or children's birthday parties, Kama is one of the leading catering service in Hong Kong. 到會美食

Profile_user

Harold Wilson posted 30 November 2021

 This structure is typically designed to bind to two targets, one on a cancer cell and one on an immune cell, activating or redirecting immune effector cells with the goal of getting the immune cell to kill the cancer cell by antibody-dependent cell-mediated cytotoxicity.


Profile_user

telobi3311 telobi3311 posted 30 November 2021

If You are looking for IQOS USA, Smoke Way com is well known for delivering the IQOS Shop Online since 2009 It is your trust and our honesty that we are able to reach here. Welcome to IQOS ERA — Smoke with Style & Pride! Use Coupon Code "welcome5" on checkout and get discount for your first order.

Profile_user

Johny Kim posted 01 December 2021

Bispecific antibodies, as its name indicates, consists of two antigen-binding sites, which can simultaneously bind two separate and unique antigens (or different epitopes of the same antigen). 

Profile_user

Joe Anderson posted 02 December 2021

Specific challenges of developing bispecific antibody therapeutics could arise at various stages. But the main restraint in the development of bispecific antibodies falls on manufacturing problems, such as low expression yields, product instability, and immunogenicity.


All the best. 

Profile_user

aliana ales posted 03 December 2021

The business plan writer, Andrew Ludlam, provides a professional and affordable business plan writing service to both startups and established companies across the UK. Get Pro Business Plan Writing Services.



Do NOT follow this link or you will be banned!